The urinary excretion of assayable vitamin B12 and radioactivity after parenteral 58Co B12 in man.
نویسنده
چکیده
Evidence is presented that after injection of radioactive vitamin B(12) in man, there is a close correlation between the amount of radioactivity excreted and the amount of assayable vitamin B(12) excreted, and thus that the amount of radioactivity excreted is a true measure of the vitamin B(12) excreted. The possible reasons for this occurrence are discussed and it is suggested that in the body vitamin B(12) does not exist as such but as an analogue or active derivative.
منابع مشابه
Heterogeneity of hepatic vitamin B12 in the rat after parenteral cyanocobalamin.
1. The rate of radioactive vitamin B12 excretion into plasma and bile from the isolated perfused rat liver and into bile in vivo has been measured after the intramuscular injection of radioactive cyanocobalamin at various time-intervals before study. 2. With an interval of labelling of 10 or more days, the release of radioactive vitamin B12 over 4 h by the isolated perfused liver was linear and...
متن کاملThe plasma clearance and urinary excretion of parenterally administered 58Co B12.
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By WILLIAM R. BEST, WILFIIID F. WHITE, KENNETH C. R-OBBINS, WENDELL A. LANDMANN AND SANFORD L. STEELMAN T HE NORMAL HUMAN INTESTINE can absorb significant amisounts of the usually ingested quantities of vitamnin B12 only in the presence of intrinsic factor. In recent years three different tests using orally admimmistered, Co#{176}#{176}-labeled vitamin B12 have beets proposed for the estimation...
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متن کاملVitamin B 12 absorption studies : effect of parenteral non - radioactive vitamin B 12 on serum level of 57 Co vitamin B 12 LILIAN
mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B12 absorption. It is su...
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 14 شماره
صفحات -
تاریخ انتشار 1961